Comprehensive Platelet Phenotypic Laboratory Testing and Bleeding History Scoring for Diagnosis of Suspected Hereditary Platelet Disorders

Current status and future prospects for platelet function testing in the diagnosis of inherited bleeding disorders.

Platelets play a crucial role in haemostasis by preventing bleeding at the site of vascular injury. Several defects in platelet morphology and function have been identified and described over the years. Although a range of methodologies is available to assess platelet function, a significant proportion of subjects with bleeding symptoms and normal coagulation parameters still appear to have nor...

Laboratory analyses for evaluation of platelet disorders and platelet concentrates

Platelet Function Disorders in Adolescents with Heavy Menstrual Bleeding: Clinical Presentations, Laboratory Testing and Treatment Options

Heavy menstrual bleeding (HMB) is a common problem in adolescent girls where it comprises a significant public health problem [1]. HMB affects almost one-third of adolescent girls at the time of the menarche. Reports from multiple studies indicate that between 5 and 10 percent of young girls in this age group will seek medical treatment and of those, approximately one-half will experience surgi...

Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders.

In the present issue of TRANSFUSION MEDICINE AND HEMOTHERAPY current strategies for the diagnosis of inherited platelet function disorders that have been established in different clinics in the German-speaking countries are summarized. These strategies are partially related to diagnostic algorithms applied in Italy or the UK [1, 2]. Inherited platelet function disorders represent a heterogeneou...

Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders

BACKGROUND The ISTH bleeding assessment tool (ISTH-BAT) was developed to record bleeding symptoms and to aid diagnosis in patients with a possible bleeding disorder. OBJECTIVES To investigate the utility of the ISTH-BAT in predicting functional defects in platelet activation in participants with suspected inherited platelet function disorders. PATIENTS/METHODS Participants with clinical evi...